Actress Kate Walsh held back nothing last night on Comedy Central’s Roast of Charlie Sheen. Walsh, who was among a group of celebrities tasked with ripping Sheen a new one, performed commendably at the podium, throwing down jabs like this one: “I have to say, Charlie, you are an incredible medical specimen. I guess that’s one of the benefits of waking up every morning at the crack of crack…It’s amazing—after abusing your lungs, liver and kidneys, the only thing you’ve had removed is your kids.”

We should also mention that Walsh looked amazing up there, once again confirming that women are even hotter when they’re being funny. Click through for pictures and a couple of Kate’s notable quips from the night.

“Admittedly, Charlie gets a little confused at times,” Walsh said at Sheen’s roast. “He’s the only guy who pulls a knife on a girl who’s already willing to f*ck him.”

Her insults weren’t focused solely on Sheen, either: “But is [Sheen] really the worst guy here? So he made a chick blow him for 30 grand. Mike Tyson makes you blow him ’cause I said so.'”

One of Walsh’s lines that got cut from the broadcast was directed at actor Jon Lovitz, who was also on stage: “Good cholesterol is anything that gives Jon Lovitz a fatal heart attack.”

Walsh is best known for her role as Dr. Addison Montgomery on ABC’s Grey’s Anatomy, and spin-off series Private Practice.

She got started in the entertainment business as a model in Japan.

Before that, she worked at a Burger King and a Dairy Queen. Everyone’s gotta start somewhere.

Her first big television appearances was a role as Drew Carey’s girlfriend on The Drew Carey Show in 1997.

Her first major part in a big-name Hollywood film was a role as Will Ferrell’s wife in Kicking and Screaming.

Early in her career, Walsh also performed in a number of off-Broadway plays, and for a time ran with the comedy troupe Burn Manhattan. Quite a diverse background.