Though hydrochlorothiazide side effects are typically fairly mild, there are others caused from the diuretic pill that should be payed close attention to. Because the "water pill" is used more for people with heart conditions or fluid retention problems, side effects of using the drug are a result of the decreased water levels in the blood, or abnormal amounts of other substances building up.
- Thirst. Because hydrochlorothiazide is a diuretic (makes you urinate), the body will have to take time to adjust to the amount of water you are going to stop retaining. The constant urination may trick your body into believing that you are not receiving enough fluids. As a result, your brain will mistakenly activate the thirst drive. Eventually after several days, this stops occurring.
- Diarrhea. The body's over-accumulation of fluids can be a dangerous thing. Consequentially, hydrochlorothiazide will begin to prevent water reabsorption in any way possible. The large intestine, after the kidneys, is an important center of water reabsorption. If your colon stops taking in more water, it will leave your stool runny. This is nothing to be alarmed about, as it should also dissipate a few days after using the drug.
- Hyperuricemia. The kidneys' ability to reabsorb resources is significantly lowered when on the medication. Unfortunately, this lack of reabsorption may also cause a decrease in the kidneys' ability to filter blood into nephrons. As a result, the amount of uric acid in the blood may steadily increase, as it cannot be transported into the nephrons where it's watered down into urea. This buildup of uric acid can eventually begin to collect in the joints, causing a condition known as gout.
- Vomiting. Every attempt to remove water from the body is exercised during the beginning stages of using hydrochlorothiazide. It's possible that the patient may have nausea and vomiting possibly due to the body being tricked into believing that there is a toxin in the stomach that needs to be removed. While the drug itself is not poisonous, its diuretic properties may confuse the body into vomiting out chyme in the stomach.
- Hyperglycemia. The decreased amount of water molecules in the blood may cause an issue that prevents glucose in the blood from transferring into the cells. As a result, glucose levels may continue to rise, causing high blood pressure, headaches, jitteriness, and followed by a crash. In rare cases, if an individual continues to increase their blood sugar levels, it can cause serious health problems that can lead to a heart attack, stroke, and comatose.
- Hyperlipidemia. As with blood sugar levels, if there is a significant decrease in water found in the blood, even though it's actually a healthier amount, the body may not be able to adjust to the change very quickly. In terms of lipids, fats that constitute for many important cellular functions, they may be over-secreted into the blood in order to make up for the volume change. Having high lipid levels in the blood can be very dangerous and they are sticky, large, and can easily cause a clot.
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